Oxford University Clinical Research Unit (OUCRU)

Oxford University Clinical Research Unit (OUCRU)

Clinical research

track_changes Track Tracking Be alerted when new articles are added in this gateway (manage your tracking alerts via your account) Stop tracking this gateway
Home Gateways Oxford University Clinical Research Unit (OUCRU)
1-19 of 19 ARTICLES
 in 
https://doi.org/10.12688/wellcomeopenres.23352.2
Case Report metrics
Revised
Case Report: Multi drug resistant tuberculosis in an 18-month-old boy with seizure, vomiting, and loss of vision
[version 2; peer review: 3 approved, 1 approved with reservations]
Mukund Kumar Deo, Amod Rayamajhi, Bimala Baniya, Susan Bhattarai, Sristi Upadhyay, Sanjeet Kumar Shrestha, Buddha Basnyat, Ajit Rayamajhi
Peer Reviewers Sachin Atre; Hussein H Twabi; Milagros Zavaleta; Dejair Caitano do Nascimento
  • Funder
  • Wellcome Trust
LATEST VERSION PUBLISHED 15 Oct 2025
https://doi.org/10.12688/wellcomeopenres.24190.1
Case Report metrics AWAITING PEER REVIEW
Case Report: Secondary Hemophagocytic Lymphohistiocytosis in a Patient with Autoimmune Hepatitis- A challenging diagnosis
[version 1; peer review: awaiting peer review]
Aashis Poudel, Himal Karki, Binita Basnet, Rehan Pradhan, Roshan Shrestha, Buddha Basnyat
Peer Reviewers Invited
  • Funder
  • Wellcome
PUBLISHED 09 Jun 2025
https://doi.org/10.12688/wellcomeopenres.22792.2
Research Article metrics
Revised
Awake prone positioning effectiveness in moderate to severe COVID-19 a randomized controlled trial.
[version 2; peer review: 4 approved]
Nguyen Thanh Phong, Du Hong Duc, Ho Bich Hai, Nguyen Thanh Nguyen, Le Dinh Van Khoa, Le Thuy Thuy Khanh, Luu Hoai Bao Tran, Nguyen Thi My Linh, Cao Thi Cam Van, Dang Phuong Thao, Nguyen Thi Diem Trinh, Pham Tieu Kieu, Nguyen Thanh Truong, Vo Tan Hoang, Nguyen Thanh Ngoc, Tran Thi Dong Vien, Vo Trieu Ly, Tran Dang Khoa, Abigail Beane, James Anibal, OUCRU COVID RESEACH GROUP, Guy E Thwaites, Ronald Geskus, David Clifton, Nguyen Thi Phuong Dung, Evelyne Kestelyn, Guy Glover, Le Van Tan, Lam Minh Yen, Nguyen Le Nhu Tung, Nguyen Thanh Dung, C Louise Thwaites
Peer Reviewers Giorgio Maraziti; Haibo Qiu; Luke A McDonald; Florence Daviet
  • Funder
  • Wellcome Trust
LATEST VERSION PUBLISHED 07 Dec 2024
https://doi.org/10.12688/wellcomeopenres.21017.1
Study Protocol metrics
Anakinra for dengue patients with hyperinflammation: protocol for a randomized double-blind placebo-controlled trial
[version 1; peer review: 2 approved, 2 approved with reservations]
Tran Bang Huyen, Huynh Trung Trieu, Nguyen Lam Vuong, Nguyen Minh Nguyet, Dong Thi Hoai Tam, Angela McBride, Nguyen Thi My Linh, Dang Trong Thuan, Nguyen Thanh Phong, Truong Ngoc Trung, Nguyen Thi Cam Huong, Tran Thi Dong Vien, Huynh Thi Le Duyen, Vo Thi My Hoa, James Watson, Ronald Geskus, Phan Vinh Tho, Evelyne Kestelyn, Phan Tu Qui, Sophie Yacoub
Peer Reviewers Arif Nur Muhammad Ansori; Gathsaurie Neelika Malavige; Panisadee Avirutnan and Dumrong Mairiang; Bachti Alisjahbana
  • Funder
  • Wellcome Trust
PUBLISHED 22 Nov 2024
https://doi.org/10.12688/wellcomeopenres.22993.1
Case Report metrics
Case Report: Unusual case of candy wrapper aspiration
[version 1; peer review: 3 approved]
Santosh Adhikari, Amod Rayamajhi, Tribhuwan Bhattarai, Shristi Upadhyay, Sanjeet Kumar Shrestha, Buddha Basnyat, Ajit Rayamajhi
Peer Reviewers Hüseyin Fatih Sezer; Alaa Gaafar; Evaristus Afiadigwe
  • Funder
  • Wellcome
PUBLISHED 16 Sep 2024
https://doi.org/10.12688/wellcomeopenres.19455.2
Study Protocol metrics
Revised
Metformin as adjunctive therapy in combination with multidrug treatment for multibacillary leprosy: A protocol for a randomized double-blind, controlled Phase 2 trial in Indonesia (MetLep Trial)
[version 2; peer review: 2 approved]
Hana Krismawati, Sri V. Muchtar, Mutia Rahardjani, Nindya N. Utami, Margareta Oktaviani, Khairunnisa Puspatriani, Syamsiah ., Nelly Imbiri, Dian E. Hasvitasari, Dwi R. Fajrianti, Nico Tarino, Fitri Wulandari, Evelyne Kestelyn, Duc H. Du, Reinout van Crevel, Stephen L. Walker, Ronald Geskus, Annemieke Geluk, Raph L. Hamers, Hardyanto Soebono, Marlous L. Grijsen
Peer Reviewers Roberto Arenas-Guzmán; Veincent Christian F Pepito
  • Funders
  • Wellcome Trust
  • Leprosy Research Initiative and Turing Foundation
LATEST VERSION PUBLISHED 09 May 2024
https://doi.org/10.12688/wellcomeopenres.18026.2
Method Article metrics
Revised
Wearable devices for remote monitoring of hospitalized patients with COVID-19 in Vietnam
[version 2; peer review: 3 approved, 1 approved with reservations]
Nguyen Van Vinh Chau, Truong Ngoc Trung, Phan Nguyen Quoc Khanh Khanh, Phung Tran Huy Nhat, Hoang Minh Tu Van, Ho Bich Hai, Duong Bich Thuy, Nguyen Le Nhu Tung, Dao Bach Khoa, Tran Thi Dong Vien, Nguyen Van Hao, Pham Kieu Ngyuyet Oanh, Tran Dang Khoa, Nguyen Thanh Phong, Nguyen Thanh Nguyen, Julie Huynh, Timothy M Walker, Jennifer Van Nuil, Luu Phuoc An, Jacob McKnight, Le Mau Toan, Le Van Tan, Nguyen Thanh Dung, Nguyen Thanh Truong, C Louise Thwaites, OUCRU COVID Research Group
Peer Reviewers Tamara Vagg; Benjamin Smarr; Deepak Berwal; Jonathan Clarke
  • Funder
  • Wellcome Trust
LATEST VERSION PUBLISHED 20 Jun 2023
https://doi.org/10.12688/wellcomeopenres.18509.1
Study Protocol metrics
Evaluation of awake prone positioning effectiveness in moderate to severe COVID-19
[version 1; peer review: 1 approved, 1 approved with reservations]
Nguyen Thanh Truong, Nguyen Thanh Phong, Nguyen Thanh Nguyen, Le Thuy Thuy Khanh, Luu Hoai Bao Tran, Nguyen Thi My Linh, Dang Phuong Thao, Nguyen Thi Diem Trinh, Pham Tieu Kieu, Nguyen Thi Phuong Thao, Vo Tan Hoang, Nguyen Thanh Ngoc, Pham Kieu Nguyet Oanh, Tran Thi Dong Vien, Nguyen Le Nhu Tung, Vo Trieu Ly, Tran Dang Khoa, Nguyen Hoan Phu, Cao Thi Cam Van, Tran Minh Duc, Abigail Beane, Le Dinh Van Khoa, David Clifton, Evelyne Kestelyn, Ho Bich Hai, Lam Minh Yen, Le Van Tan, Guy Glover, Guy E Thwaites, Ronald Geskus, Du Hong Duc, Nguyen Thanh Dung, C Louise Thwaites
Peer Reviewers Oriol Roca; Akhilesh Jha and Fangyue Chen
  • Funder
  • Wellcome Trust
PUBLISHED 05 Jun 2023
https://doi.org/10.12688/wellcomeopenres.16770.3
Study Protocol metrics
Revised
Study protocol: The clinical features, epidemiology, and causes of paediatric encephalitis in southern Vietnam
[version 3; peer review: 2 approved]
Nguyen Hoang Thien Huong, Nguyen Duc Toan, Du Tuan Quy, Truong Huu Khanh, Le Quoc Thinh, Le Nguyen Thanh Nhan, Ngo Ngoc Quang Minh, Hugo Turner, Louise Thwaites, Sarosh Irani, Nguyen Thanh Hung, Le Van Tan
Peer Reviewers Elizabeth M. Molyneux; Emma C. Thomson
  • Funders
  • Wellcome Trust
  • Gates Foundation
LATEST VERSION PUBLISHED 13 Sep 2022
https://doi.org/10.12688/wellcomeopenres.17154.2
Study Protocol metrics
Revised
A statistical analysis plan for the Adjunctive Corticosteroids for Tuberculous meningitis in HIV-positive adults (ACT HIV) clinical trial
[version 2; peer review: 3 approved]
Joseph Donovan, Trinh Dong Huu Khanh, Guy E. Thwaites, Ronald B. Geskus, ACT HIV investigators
Peer Reviewers Nico (Nicolaas) Nagelkerke; Ravindra Kumar Garg and Hardeep Singh Malhotra; Peter Mwaba
  • Funder
  • Wellcome Trust
LATEST VERSION PUBLISHED 07 Jul 2022
https://doi.org/10.12688/wellcomeopenres.16053.2
Study Protocol metrics
Revised
Metformin as adjunctive therapy for dengue in overweight and obese patients: a protocol for an open-label clinical trial (MeDO)
[version 2; peer review: 3 approved]
Nguyen Minh Nguyet, Ho Quang Chanh, Dong Thi Hoai Tam, Nguyen Lam Vuong, Nguyen Thi Xuan Chau, Nguyen Van Vinh Chau, Nguyen Thanh Phong, Huynh Trung Trieu, Tai Luong Thi Hue, Tam Cao Thi, Trung Dinh The, Huynh Thi Le Duyen, Ninh Thi Thanh Van, Quyen Nguyen Than Ha, Laura Rivino, Peter Gallagher, Nick K. Jones, Ronald B. Geskus, Evelyne Kestelyn, Sophie Yacoub
Peer Reviewers Eng Eong Ooi; Quirijn de Mast; Rosa María del Ángel and Juan Fidel Osuna-Ramos
  • Funder
  • Wellcome Trust
LATEST VERSION PUBLISHED 08 Feb 2021
https://doi.org/10.12688/wellcomeopenres.16175.2
Case Report metrics
Revised
Case Report: Pulmonary tuberculosis and raised transaminases without pre-existing liver disease- Do we need to modify the antitubercular therapy?
[version 2; peer review: 1 approved, 2 approved with reservations]
Sanjeev Gautam, Keshav Raj Sigdel, Sudeep Adhikari, Buddha Basnyat, Buddhi Paudyal, Jiwan Poudel, Ujjwol Risal
Peer Reviewers Vivek Neelakantan; Prajowl Shrestha and Ashesh Dhungana; Neesha Rockwood
  • Funder
  • Wellcome Trust
LATEST VERSION PUBLISHED 16 Oct 2020
https://doi.org/10.12688/wellcomeopenres.16093.1
Study Protocol metrics
The CIPAZ study protocol: an open label randomised controlled trial of azithromycin versus ciprofloxacin for the treatment of children hospitalised with dysentery in Ho Chi Minh City, Vietnam
[version 1; peer review: 2 approved with reservations]
Thomas C. Darton, Tran Thi Hong Chau, Christopher M. Parry, James I. Campbell, Nguyen Minh Ngoc, Tang Le Chau Ngoc, Ha Thanh Tuyen, Vu Thuy Duong, Le Thanh Hoang Nhat, Pham van Minh, Evelyne Kestelyn, Guy E. Thwaites, Trinh Huu Tung, Stephen Baker
Peer Reviewers David A. Sack; Judd Walson
  • Funders
  • Wellcome Trust
  • Academy of Medical Sciences
  • Health Services Research Programme
PUBLISHED 11 Sep 2020
https://doi.org/10.12688/wellcomeopenres.15837.2
Case Report metrics
Revised
Case Report: Co-existence of sarcoidosis and Takayasu arteritis
[version 2; peer review: 2 approved, 1 approved with reservations]
Jiwan Poudel, Ujjwol Risal, Keshav Raj Sigdel, Buddhi Prasad Paudyal, Sudeep Adhikari, Buddha Basnyat
Peer Reviewers Varun Dhir; Debashish Danda; Hollis E. Krug
  • Funder
  • Wellcome Trust
LATEST VERSION PUBLISHED 23 Jul 2020
https://doi.org/10.12688/wellcomeopenres.15010.1
Study Protocol metrics
A randomized open label trial of tamoxifen combined with amphotericin B and fluconazole for cryptococcal meningitis.
[version 1; peer review: 2 approved, 1 approved with reservations]
Nguyen Thi Thuy Ngan, Nguyen Thi Hoang Mai, Nguyen Le Nhu Tung, Nguyen Phu Huong Lan, Luong Thi Hue Tai, Nguyen Hoan Phu, Nguyen Van Vinh Chau, Tran Quang Binh, Le Quoc Hung, Justin Beardsley, Nicholas J. White, David G. Lalloo, Damian Krysan, William Hope, Ronald Geskus, Marcel Wolbers, Le Thanh Hoang Nhat, Guy E Thwaites, Evelyne Kestelyn, Jeremy N. Day
Peer Reviewers Joshua Rhein; William G Powderly; Peter R. Williamson
  • Funder
  • Wellcome Trust
PUBLISHED 22 Jan 2019
https://doi.org/10.12688/wellcomeopenres.14587.2
Study Protocol metrics
Revised
Intrathecal Immunoglobulin for treatment of adult patients with tetanus: A randomized controlled 2x2 factorial trial
[version 2; peer review: 2 approved]
Huỳnh Thị Loan, Lam Minh Yen, Evelyne Kestelyn:, Nguyen Van Hao, Tran Tan Thanh, Nguyen Thi Phuong Dung, Hugo C. Turner, Ronald B. Geskus, Marcel Wolbers, Le Van Tan, H. Rogier Van Doorn, Nicholas P. Day, Duncan Wyncoll, Tran Tinh Hien, Guy E. Thwaites, Nguyen Van Vinh Chau, C. Louise Thwaites
Peer Reviewers Joanne M. Langley; Philip Bejon
  • Funder
  • Wellcome Trust
LATEST VERSION PUBLISHED 05 Nov 2018
https://doi.org/10.12688/wellcomeopenres.14006.2
Study Protocol metrics
Revised
Adjunctive dexamethasone for the treatment of HIV-infected adults with tuberculous meningitis (ACT HIV): Study protocol for a randomised controlled trial
[version 2; peer review: 1 approved, 2 approved with reservations]
Joseph Donovan, Nguyen Hoan Phu, Nguyen Thi Hoang Mai, Le Tien Dung, Darma Imran, Erlina Burhan, Lam Hong Bao Ngoc, Nguyen Duc Bang, Do Chau Giang, Dang Thi Minh Ha, Jeremy N. Day, Le Thi Phuong Thao, Nguyen TT Thuong, Nguyen Nang Vien, Ronald B. Geskus, Marcel Wolbers, Raph L. Hamers, Reinout van Crevel, Mugi Nursaya, Kartika Maharani, Tran Tinh Hien, Kevin Baird, Nguyen Huu Lan, Evelyne Kestelyn, Nguyen Van Vinh Chau, Guy E. Thwaites
Peer Reviewers Ravindra Kumar Garg; Rohit Bhatia and Manish Modi; Srushti Gandhi and Ira Shah
  • Funder
  • Wellcome Trust
LATEST VERSION PUBLISHED 20 Jun 2018
https://doi.org/10.12688/wellcomeopenres.12429.2
Research Article metrics
Revised
Evaluation of the Luminex xTAG Respiratory Viral Panel FAST v2 assay for detection of multiple respiratory viral pathogens in nasal and throat swabs in Vietnam
[version 2; peer review: 2 approved]
Vu Thi Ty Hang, Nguyen Thi Han Ny, Tran My Phuc, Pham Thi Thanh Tam, Dang Thao Huong, Ho Dang Trung Nghia, Nguyen Tran Anh Vu, Pham Thi Hong Phuong, Nguyen Van Xang, Nguyen Dong, Pham Nhu Hiep, Nguyen Van Hung, Tran Tinh Hien, Maia Rabaa, Guy E. Thwaites, Stephen Baker, Le Van Tan, H.Rogier van Doorn, VIZIONS consortium
Peer Reviewers Bharti Malhotra; Marta Canuti
  • Funder
  • Wellcome Trust
LATEST VERSION PUBLISHED 30 Apr 2018
https://doi.org/10.12688/wellcomeopenres.14007.1
Study Protocol metrics
Adjunctive dexamethasone for the treatment of HIV-uninfected adults with tuberculous meningitis stratified by Leukotriene A4 hydrolase genotype (LAST ACT): Study protocol for a randomised double blind placebo controlled non-inferiority trial
[version 1; peer review: 2 approved]
Joseph Donovan, Nguyen Hoan Phu, Le Thi Phuong Thao, Nguyen Huu Lan, Nguyen Thi Hoang Mai, Nguyen Thi Mai Trang, Nguyen Thi Thu Hiep, Tran Bao Nhu, Bui Thi Bich Hanh, Vu Thi Phuong Mai, Nguyen Duc Bang, Do Chau Giang, Dang Thi Minh Ha, Jeremy N. Day, Nguyen TT Thuong, Nguyen Nang Vien, Ronald B. Geskus, Tran Tinh Hien, Evelyne Kestelyn, Marcel Wolbers, Nguyen Van Vinh Chau, Guy E. Thwaites
Peer Reviewers Ravindra Kumar Garg; Katalin A. Wilkinson
  • Funder
  • Wellcome Trust
PUBLISHED 20 Mar 2018
1-19 of 19 ARTICLES
Gateway Areas
Our News
Our Links

Are you a Wellcome-funded researcher?

If you are a previous or current Wellcome grant holder, sign up for information about developments, publishing and publications from Wellcome Open Research.

You must provide your first name
You must provide your last name
You must provide a valid email address
You must provide an institution.

Thank you!

We'll keep you updated on any major new updates to Wellcome Open Research

Sign In
If you've forgotten your password, please enter your email address below and we'll send you instructions on how to reset your password.

The email address should be the one you originally registered with F1000.
Email address not valid, please try again

You registered with F1000 via Google, so we cannot reset your password.

To sign in, please click here.

If you still need help with your Google account password, please click here.

You registered with F1000 via Facebook, so we cannot reset your password.

To sign in, please click here.

If you still need help with your Facebook account password, please click here.

Code not correct, please try again
Email us for further assistance.
Server error, please try again.