KEMRI | Wellcome Trust

KEMRI | Wellcome Trust

Clinical Research

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21-38 of 38 ARTICLES
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 in 
https://doi.org/10.12688/wellcomeopenres.15627.1
Research Article metrics
Comparing drug regimens for clearance of malaria parasites in asymptomatic adults using PCR in Kilifi County, Kenya: an open-label randomised controlled clinical trial (MalPaC)
[version 1; peer review: 2 approved with reservations]
Emma Nelima Khaemba, Caroline Ogwang, Sam M. Kinyanjui, John Mutiso Muindi, Joseph Kipsigei Koske, Domtila Kimani, Joyce Ngoi, Jedidah Mwacharo, Jimmy Shangala, Patricia Njuguna, Dennis Mutinda, Emily Nyatichi, Judy Peshu, Brian Mutinda, Francis M. Ndungu, Anna Farnert, Mahfudh M. Bashraheil, Philip Bejon, Melissa C. Kapulu
Peer Reviewers Ingrid Felger; Michael Hawkes
  • Funders
  • Wellcome Trust
  • European and Developing Countries Clinical Trials Partnership
PUBLISHED 20 Feb 2020
https://doi.org/10.12688/wellcomeopenres.15314.4
Research Article metrics
Revised
Cost-effectiveness of oral versus intravenous antibiotics (OVIVA) in patients with bone and joint infection: evidence from a non-inferiority trial
[version 4; peer review: 2 approved]
Nicola McMeekin, Claudia Geue, Andrew Briggs, Ines Rombach, Ho Kwong Li, Philip Bejon, Martin McNally, Bridget L. Atkins, Jamie Ferguson, Matthew Scarborough, OVIVA collaborators
Peer Reviewers Simon Dixon; Diarmuid Coughlan
  • Funders
  • Wellcome Trust
  • National Institute for Health Research
LATEST VERSION PUBLISHED 08 Jan 2020
https://doi.org/10.12688/wellcomeopenres.15579.1
Study Protocol metrics
Randomized, double-blinded, controlled non-inferiority trials evaluating the immunogenicity and safety of fractional doses of Yellow Fever vaccines in Kenya and Uganda
[version 1; peer review: 2 approved]
Derick Kimathi, Aitana Juan, Philip Bejon, Rebecca F. Grais, George M. Warimwe, YEFE and NIFTY vaccine trials teams
Peer Reviewers Anna H. E. Roukens; Akira Homma
  • Funders
  • Wellcome Trust
  • European and Developing Countries Clinical Trials Partnership
  • African Academy of Sciences
  • Médecins Sans Frontières
  • Tropical Network Fund, University of Oxford
  • Oak Foundation
PUBLISHED 20 Nov 2019
https://doi.org/10.12688/wellcomeopenres.15568.1
Research Article metrics
Congenital microcephaly unrelated to flavivirus exposure in coastal Kenya
[version 1; peer review: 2 approved, 1 approved with reservations]
Hellen C. Barsosio, John N. Gitonga, Henry K. Karanja, Doris K. Nyamwaya, Donwilliams O. Omuoyo, Everlyn Kamau, Mainga M. Hamaluba, Joyce U. Nyiro, Barnes S. Kitsao, Amek Nyaguara, Stella Mwakio, Charles R. Newton, Rosemary Sang, Daniel Wright, Eduard J. Sanders, Anna C. Seale, Charles N. Agoti, James A. Berkley, Philip Bejon, George M. Warimwe
Peer Reviewers Lavinia Schuler-Faccini; Jan Felix Drexler and Thomas Jaenisch; Helen Dolk
  • Funders
  • Wellcome Trust
  • Medical Research Council
  • Gates Foundation
  • Newton Fund
PUBLISHED 15 Nov 2019
https://doi.org/10.12688/wellcomeopenres.14909.2
Study Protocol metrics
Revised
Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA): a study protocol to investigate in vivo Plasmodium falciparum malaria parasite growth in the context of pre-existing immunity
[version 2; peer review: 2 approved]
Melissa C. Kapulu, Patricia Njuguna, Mainga M. Hamaluba, CHMI-SIKA Study Team
Peer Reviewers Alister G. Craig; Salim Abdulla
  • Funders
  • Wellcome Trust
  • University of Oxford
LATEST VERSION PUBLISHED 14 Nov 2019
https://doi.org/10.12688/wellcomeopenres.15302.1
Research Article metrics
Competing risk survival analysis of time to in-hospital death or discharge in a large urban neonatal unit in Kenya
[version 1; peer review: 3 approved]
Jalemba Aluvaala, Gary S. Collins, Beth Maina, Catherine Mutinda, Mary Wayiego, James A. Berkley, Mike English
Peer Reviewers Elizabeth M. Molyneux; Alison A. Leaf; Cheryl Battersby
  • Funders
  • Wellcome Trust
  • Economic and Social Research Council
  • Department for International Development, UK Government
  • Medical Research Council
PUBLISHED 17 Jun 2019
https://doi.org/10.12688/wellcomeopenres.14801.2
Research Article metrics
Revised
Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe  anaemia in hospitalised children in Eastern Uganda
[version 2; peer review: 3 approved]
Peter Olupot-Olupot, Natalie Prevatt, Charles Engoru, Julius Nteziyaremye, Denis Amorut, Martin Chebet, Tonny Senyondo, Paul Ongodia, Carolyne M. Ndila, Thomas N. Williams, Kathryn Maitland
Peer Reviewers Dora Mbanya; Jean‐Pierre Allain; Walter H Dzik
  • Funders
  • Wellcome Trust
  • Imperial College London
LATEST VERSION PUBLISHED 18 Mar 2019
https://doi.org/10.12688/wellcomeopenres.15108.1
Research Article metrics
Agreement between ELISA and plaque reduction neutralisation assay in Detection of respiratory syncytial virus specific antibodies in a birth Cohort from Kilifi, coastal Kenya.
[version 1; peer review: 2 approved, 2 approved with reservations]
Joyce U. Nyiro, Patience K. Kiyuka, Martin N. Mutunga, Charles J. Sande, Patrick K. Munywoki, J. Anthony G. Scott, D. James Nokes
Peer Reviewers Ting Shi; Shabir A. Madhi; Helen Y. Chu; Pedro A. Piedra
  • Funders
  • Wellcome Trust
  • PATH
PUBLISHED 18 Feb 2019
https://doi.org/10.12688/wellcomeopenres.14882.1
Systematic Review metrics
Health risk behavior among perinatally HIV exposed uninfected adolescents: A systematic review
[version 1; peer review: 2 approved with reservations]
Derrick Ssewanyana, Patrick N Mwangala, Moses Kachama Nyongesa, Anneloes van Baar, Charles R Newton, Amina Abubakar
Peer Reviewers Farhad Shokraneh; Arvin Bhana
  • Funders
  • Wellcome Trust
  • Department for International Development, UK Government
  • Medical Research Council
PUBLISHED 29 Oct 2018
https://doi.org/10.12688/wellcomeopenres.11768.2
Research Article metrics
Revised
Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters
[version 2; peer review: 3 approved]
Loise Ndung'u, Benard Langat, Esther Magiri, Joseph Ng'ang'a, Beatrice Irungu, Alexis Nzila, Daniel Kiboi
Peer Reviewers Axel Martinelli; David A. Fidock; Richard T. Eastman
  • Funders
  • Wellcome Trust
  • DELTAS Africa Initiative
  • Pan African University
LATEST VERSION PUBLISHED 06 Jun 2018
https://doi.org/10.12688/wellcomeopenres.11728.2
Method Article metrics
Revised
Liquid chromatography–tandem mass spectrometry for the simultaneous quantitation of ceftriaxone, metronidazole and hydroxymetronidazole in plasma from seriously ill, severely malnourished children
[version 2; peer review: 3 approved, 1 approved with reservations]
Martin Ongas, Joseph Standing, Bernhards Ogutu, Joseph Waichungo, James A. Berkley, Karin Kipper
Peer Reviewers Laurens Manning; I-Lin Tsai; Sandrine Lefeuvre; Pascal Houzé
  • Funders
  • Wellcome Trust
  • Eesti Teadusagentuur
  • National Institute for Health Research
  • Department for International Development, UK Government
  • Medical Research Council
  • Seventh Framework Programme
  • Gates Foundation
LATEST VERSION PUBLISHED 30 Jan 2018
https://doi.org/10.12688/wellcomeopenres.12747.2
Study Protocol metrics
Revised
Children’s Oxygen Administration Strategies Trial (COAST):  A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia
[version 2; peer review: 2 approved]
Kathryn Maitland, Sarah Kiguli, Robert O. Opoka, Peter Olupot-Olupot, Charles Engoru, Patricia Njuguna, Victor Bandika, Ayub Mpoya, Andrew Bush, Thomas N. Williams, Richard Grieve, Zia Sadique, John Fraser, David Harrison, Kathy Rowan
Peer Reviewers Steve Cunningham; Daniel S. Martin
  • Funders
  • Wellcome Trust
  • Medical Research Council
LATEST VERSION PUBLISHED 09 Jan 2018
https://doi.org/10.12688/wellcomeopenres.12620.1
Research Article metrics
Psychometric evaluation of the Major Depression Inventory among young people living in Coastal Kenya
[version 1; peer review: 2 approved]
Mark Otiende, Amina Abubakar, George Mochamah, David Walumbe, Christopher Nyundo, Aoife M Doyle, David A Ross, Charles R Newton, Evasius Bauni
Peer Reviewers Sven Rabung and Kristina Abing; Glyn Lewis
  • Funder
  • Wellcome Trust
PUBLISHED 29 Nov 2017
https://doi.org/10.12688/wellcomeopenres.12357.3
Systematic Review metrics
Revised
Oral rehydration of malnourished children with diarrhoea and dehydration: A systematic review
[version 3; peer review: 2 approved]
Kirsty A. Houston, Jack G. Gibb, Kathryn Maitland
Peer Reviewers André Briend; Maren Johanne Heilskov Rytter
  • Funder
  • Wellcome Trust
LATEST VERSION PUBLISHED 27 Oct 2017
https://doi.org/10.12688/wellcomeopenres.11958.2
Research Article metrics
Revised
Cerebrospinal fluid markers to distinguish bacterial meningitis from cerebral malaria in children
[version 2; peer review: 2 approved]
James M. Njunge, Ian N. Oyaro, Nelson K. Kibinge, Martin K. Rono, Symon M. Kariuki, Charles R. Newton, James A. Berkley, Evelyn N. Gitau
Peer Reviewers Wilson L. Mandala; Clarissa Valim
  • Funder
  • Wellcome Trust
LATEST VERSION PUBLISHED 26 Sep 2017
https://doi.org/10.12688/wellcomeopenres.12346.1
Systematic Review metrics
Intravenous rehydration of malnourished children with acute gastroenteritis and severe dehydration: A systematic review
[version 1; peer review: 3 approved]
Kirsty A. Houston, Jack G. Gibb, Kathryn Maitland
Peer Reviewers Elizabeth M. Molyneux; Michael Yung; Bhargavi Rao
  • Funder
  • Wellcome Trust
PUBLISHED 18 Aug 2017
https://doi.org/10.12688/wellcomeopenres.12261.1
Study Protocol metrics
Gastroenteritis Aggressive Versus Slow Treatment For Rehydration (GASTRO). A pilot rehydration study for severe dehydration: WHO plan C versus slower rehydration
[version 1; peer review: 2 approved]
Kirsty A. Houston, Jack G. Gibb, Ayub Mpoya, Nchafatso Obonyo, Peter Olupot-Olupot, Margeret Nakuya, Jennifer A Evans, Elizabeth C. George, Diana M. Gibb, Kathryn Maitland
Peer Reviewers Srinivas Murthy; Melissa Parker
  • Funders
  • Wellcome Trust
  • Medical Research Council
PUBLISHED 10 Aug 2017
https://doi.org/10.12688/wellcomeopenres.10658.2
Systematic Review metrics
Revised
Antimalarial drugs and the prevalence of mental and neurological manifestations: A systematic review and meta-analysis
[version 2; peer review: 2 approved]
Mary A. Bitta, Symon M. Kariuki, Clifford Mwita, Samson Gwer, Leah Mwai, Charles R.J.C. Newton
Peer Reviewers André Silva-Pinto; Melissa Gladstone
  • Funder
  • Wellcome Trust
LATEST VERSION PUBLISHED 02 Jun 2017
21-38 of 38 ARTICLES
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